The mesotherapy has always been the “millionaire” player in the light medical beauty project, easy to operate, fast results, loved by the majority of beauty seekers. And in the mesotherapy popular at the moment, the regulatory also came in response. With the release of the new regulations, it was included in the regulation of Class III devices, the uneven situation will be improved, “mesotherapy” also officially into the process of compliance.

We all know that the mesotherapy is a kind of beauty therapy, which essentially uses the “transdermal drug delivery” technology to help the skin quickly open the skin channel, making the “pure HA class” of the basic hydration agent or HA agent rich in a variety of nutrients into it.

In addition to hydration-injections/mesotherapy, what else can be used in Light Medical Beauty to help open up the “skin absorption channel” for better absorption using transdermal drug delivery technology?

What is transdermal drug delivery?

As clearly stated in “Research Progress in Transdermal Drug Delivery System and Application of Microneedles”, transdermal drug delivery system refers to a new form of drug delivery that allows drugs to pass through the skin barrier and enter the capillaries in the dermis by physical and chemical means, so that they can be absorbed and used by the body.

The outermost layer of our human skin has a skin barrier, which is composed of sebaceous membrane and stratum corneum. The outermost sebaceous membrane is responsible for the secretion of oil, while the stratum corneum is composed of keratinocytes and intercellular lipids.

At present, we transdermal absorption mainly through sweat glands hair follicles, intracellular keratinocytes and intercellular lipids these three pathways, the stratum corneum accounts for a larger proportion of the skin area, and its is the main way of transdermal absorption of drug components. However, it is like a tight “brick wall” that prevents the easy loss of internal water and also isolates external stimuli, limiting the penetration of drugs.

That is to say, under normal circumstances any drug into the classification of products are difficult to cross this layer of restrictions, to achieve real sense of improvement, and the emergence of products such as mesotherapy has changed this, its direct injection to achieve the effect of transdermal absorption. In addition to this, the other methods we normally use today to promote transdermal absorption are microneedling/Nano-crystal introduction (https://www.sunhingtech.com/product-category/dr-pen-led-membranes/), ultrasonic introduction method/chemical resurfacing (https://www. sunhingtech.com/product-category/hydra-facial/), etc.

Other ways of transdermal absorption

1. Microneedling
Microneedling, by means of minimally invasive skin breaking, is used to open up skin absorption channels and improve the absorption and penetration of drugs or potent ingredients. It can not only promote the absorption of ingredients, but also produce mechanical physical stimulation, induce the skin to open self-repair mechanism, accelerate epidermal metabolism, and promote collagen regeneration.

2. Ultrasonic introduction
Ultrasonic introduction refers to the use of ultrasonic energy to promote transdermal absorption of drug ingredients after local application of drug ingredients on the skin. Generally speaking, the effect of low-frequency ultrasound in promoting permeation is better than that of high-frequency ultrasound. In general, low-frequency ultrasound has a better effect than high-frequency ultrasound in promoting permeation. In the process of transmission, this sound wave also produces thermal effects and cavitation bubbles, which disrupt the lipid bilayer and make it disorderly, thus opening the channel of skin absorption and helping the drug penetrate into the skin.

3. Nano-crystal introduction
Nanocrystals, made of single-crystal silicon, have a fine nano-tip diameter and a skin penetration depth of about 150µm. The principle of introduction is similar to microneedling, but nanocrystals are used to overcome the skin’s barrier layer through nano-point array technology to open skin channels for better absorption of drug ingredients.

4. Chemical skin resurfacing
Chemical resurfacing refers to the use of osmogenic agents such as salicylic acid, fruit acid, azelaic acid, etc. to open the skin channels for penetration and absorption. Acid components are exfoliating in nature, which not only degrade the connection between keratin cells, clear the cells blocked in the sebaceous glands, and play a role in unblocking the excretion of sebaceous glands, but also promote the shedding of the aging keratin layer and accelerate the renewal and metabolism of keratinocytes to allow better penetration of subsequent drug ingredients.

When the acid component penetrates into the dermis, it can also promote collagen synthesis, increase the density of collagen fibers and elastic fibers, and regenerate the epidermis, making the skin elastic.

With the development of the medical aesthetic industry, various technologies are being updated and iterated. Hebei Sunhingtech Co.,Ltd is willing to work with you to decode the new direction of medical beauty market and build the future of light medical beauty.


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